MODULE 1. FERTILITY

1. UNIT 1. FEMALE ANATOMY AND PHYSIOLOGY
2. External genitalia
3. - Mount of Venus
4. - Labia majora
5. - Labia minora or nymphae
6. - Clitoris
7. - Vestibule
8. - Hymen
9. Internal genitalia
10. - Ovaries
11. - Fallopian tubes or oviducts
12. - Uterus
13. Attachment of the genital apparatus
14. Arterial and venous vascularization, lymphatics and innervation of the genital apparatus
15. Pelvic lymphatic vessels
16. Mammary gland
18. UNIT DIDACTIC 2. MALE ANATOMY AND PHYSIOLOGY
19. Introduction
20. Testicles
21. Spermatic pathways
22. Prostate
23. Penis
24. Male urethra
26. TEACHING UNIT 3. FEMALE SEXUAL CYCLE
27. Overview of the female sexual cycle
28. Components of the female sexual cycle
29. - Ovarian cycle
30. - Endometrial cycle
31. - Cervical cycle
32. - Endocervical cycle
33. - Myometrial cycle
34. - Vaginal cycle
35. - Tubal cycle
36. - Mammary cycle
37. Identification of fertile days
39. TEACHING UNIT 4. HUMAN REPRODUCTION
40. Biological process of reproduction
41. Cell division
42. - Mitosis
43. - Meiosis
44. Gamete formation: gametogenesis
45. - Spermatogenesis
46. - Ovogenesis
47. Fertilization and phases of embryonic development
48. - First phase: from ovulation to implantation
49. - Second phase: formation of the bilaminar germinative disc (2nd week)
50. - Third phase: formation of the trilaminar germinative disc (3rd week)
52. TEACHING UNIT 5. FERTILITY CONTROL: CONTRACEPTION
53. Contraception and choice of contraceptive method
54. - Method profile
55. - User profile
56. - Medical criteria
57. Contraceptive methods
58. - Natural contraceptive methods
59. - Barrier contraceptive methods
60. - Hormonal methods
61. - IUD: Intrauterine Device
62. - Irreversible methods, surgical methods
64. UNIT DIDACTIC 6. MALE AND FEMALE STERILITY AND INFERTILITY
65. Fertility, infertility and sterility
66. - Etiology of male infertility
67. - Etiology of female infertility
68. Diagnostic methods
69. - Diagnostic methods of male infertility
70. - Diagnostic methods of female infertility
71. Treatment of infertility
72. - Ovulation induction
73. - Artificial insemination
74. - In vitro fertilization
76. UNIT 7. BASIC NOVICES OF CONGENITAL DEFECTS
77. Introduction: congenital anomalies
78. - Causes and risk factors
79. - Prevention
80. - Screening
81. - Detection
82. Definitions
83. - Congenital anomalies
84. - Genetic diseases
85. Dysmorphology: pathogenic mechanisms
86. Types of congenital anomalies
87. - According to severity
88. - According to number
89. Etiology
91. TEACHING UNIT 8. CONGENITAL DEFECTS: CHROMOSOMIC, MONOGENIC AND MULTIFACTORAL ANOMALIES
92. Introduction to chromosomal abnormalities
93. Aneuploidy
94. - Autosomal aneuploidies
95. - Sex chromosome aneuploidy
96. Variations in chromosome structure
97. - Mosaicism
98. - Deletions
99. - Translocations
100. Sex-linked alterations
101. Congenital malformations
102. Monogenic diseases
103. - Autosomal dominant diseases
104. - Autosomal recessive diseases
105. - X-linked diseases
106. Multifactorial anomalies
108. UNIT DIDACTIC 9. CONGENITAL DEFECTS: TERATOGENIC PRINCIPLES
109. Teratogenic factors influencing gestational development
110. - Principles of theranogenesis
111. Alcohol
112. Tobacco
113. Drug dependence
114. - Cocaine
115. - Marijuana, hashish and cannabis
116. - Amphetamines
117. - Heroin
118. - Others
119. Toxic substances
120. Radiation
121. Stress
123. TEACHING UNIT 10. ABORTION
124. Introduction to abortion
125. Classification
126. Clinical forms
127. Methods of abortion
128. - Surgical methods
129. - Chemical methods
130. Complications

MODULE 2. ASSISTED HUMAN REPRODUCTION

1. TEACHING UNIT. HUMAN REPRODUCTION
2. Biological process of reproduction
3. - Cell division
4. - Gamete formation: gametogenesis
5. Anatomy of the female reproductive organs
6. - Internal genital organs
7. - External genital organs
8. Physiology of the female reproductive system
9. - Female reproductive cycle
10. - Female hormonal system
11. - Functions of female hormones
12. - Causes of menstruation
13. Breasts: anatomy and structure
14. Anatomy and physiology of male reproductive organs
15. - External genitalia
16. - Internal genitalia
17. - Auxiliary genitalia
18. - Male hormones
20. TEACHING UNIT 2. SEXUAL DIFFERENTIATION
21. Genetic basis of sexual differentiation
22. Processes influencing diformism
23. - Internal genital differentiation
24. - External genital differentiation
25. - Neurological differentiation
26. Sex hormones
27. Developmental abnormalities in sexual differentiation
29. TEACHING UNIT 3. FERTILIZATION AND PRENATAL DEVELOPMENT
30. Fertilization and phases of embryonic development
31. - First phase: from ovulation to implantation
32. - Second phase: Bilaminar germinative disc formation (2nd week)
33. - Third phase: trilaminar germinative disc formation (3rd week)
34. Embryonic period
35. Fetal period
36. - First month of pregnancy
37. - Second month of pregnancy
38. - Third month of pregnancy
39. - Fourth month of pregnancy
40. - Fifth month of pregnancy
41. - Sixth month of pregnancy
42. - Seventh month of pregnancy
43. - Eighth month of pregnancy
44. - Ninth month of pregnancy
45. The placenta
46. - Structure of the placenta
47. - Functions of the placenta
48. - Amniotic fluid
50. TEACHING UNIT 4. INTRODUCTION TO ASSISTED HUMAN REPRODUCTION.
51. Concepts
52. How many couples are affected by these disorders?
53. When should one seek help when faced with a possible reproductive limitation?
54. Causal factor of infertility
55. Assisted reproductive techniques
56. - Artificial insemination (AI)
57. - In vitro fertilization (IVF)
58. - Egg donation
60. UNIDAD DIDÁCTICA 5. MALE AND FEMALE ANAMNESIS
61. Causes of female infertility
62. - Age
63. - Weight
64. - Cycle disorders
65. - Fallopian tube and uterine diseases
66. - Cervical mucus disorders
67. Causes of male infertility
68. - Age
69. - Weight
70. - Poor semen quality
71. - Retrograde ejaculation
72. - Cryptorchidism
73. - Varicocele
74. - Vasectomy
76. UNIT 6. FERTILITY STUDY
77. Introduction to fertility study
78. Gynecological study
79. - Anamnesis
80. - Blood tests
81. - Gynecological ultrasound
82. - Hysterosalpingography
83. - Hysteroscopy
84. - Laparoscopy
85. Andrological study
86. - Spermiogram (semen analysis)
87. - Sperm capacitation test
88. - Sperm culture and survival
89. - Sperm DNA fragmentation
90. - Sperm selection by magnetic separation
91. - Ultrasound (Echo-Doppler) testicular
92. - Deferentovesiculography
93. - Testicular biopsy
94. - Cytogenetic studies
95. Psychological study
97. UNIT DIDACTIC 7. ASSISTED HUMAN REPRODUCTION TECHNIQUES (ART)
98. Introduction to ART treatments
99. Artificial Insemination (AI)
100. - Artificial Spousal Insemination (AI)
101. - Artificial Donor Insemination (AID)
102. In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI)
103. - Offer criteria
104. - General IVF/ICSI procedure
105. - Chances of success
106. - Risks of IVF/ICSI
108. UNIT DIDACTIC 8. COMPLEMENTARY TECHNIQUES OF ASSISTED HUMAN REPRODUCTION
109. Ovulation induction
110. Preimplantation Genetic Diagnosis (PGD)
111. - Indications of the technique
112. - Description of the process
113. Oocyte donation
114. - Causes for resorting to egg donation
115. - Egg donation procedure
116. Sperm retrieval
117. - Sperm retrieval procedure
118. - Chances of success of the technique
119. Fertility preservation
121. UNIT 9. LABORATORIES FOR CARRYING OUT ASSISTED HUMAN REPRODUCTION
122. Clinical analysis laboratories
123. - Laboratory organization
124. Safety and risk prevention in the clinical analysis laboratory
125. - Chemical risks
126. - Physical risks
127. - Physical and postural load
128. - Biological risks
129. - Hazards and accidents in the analysis laboratory
130. Clinical laboratory resources required for each technique
131. - General information about the AI laboratory
132. - General information about the IVF/ICSI laboratory
133. - General information about the sperm bank laboratory
134. - General information about the high biological safety laboratory (LASB)
136. UNIT 10. LEGISLATION RELATED TO ASSISTED HUMAN REPRODUCTION
137. Regulations on Assisted Human Reproduction
138. - National regulations governing Assisted Human Reproduction
139. - National regulations governing Assisted Human Reproduction
140. Regulations on Assisted Human Reproduction Techniques

MODULE 3. GENETICS AND REPRODUCTION

1. UNIT 1. INTRODUCTION TO GENETICS
2. History and development of human genetics
3. Basic concepts of genetics
4. - Cell cycle
5. - Mitosis
6. - Meiosis
7. - Gametogenesis
8. - Epigenetics
9. - Inheritance and environment
10. The Human Genome
11. - Genetic DNA
12. - Extragenic DNA
13. Characteristics of DNA and how it stores information
15. TEACHING UNIT 2. HUMAN CHROMOSOMES.
16. Definition of chromosome
17. - Distinct elements in chromosome structure
18. Shape and size of chromosomes
19. Special types of chromosomes
20. Chromosome culture and material processing
21. - Chromosome staining and banding methods
22. Cytogenetic nomenclature
23. Chromosopathies
25. UNIT TEACHING 3. METHODOLOGICAL BASIS OF MEDICAL GENETICS
26. History of medical genetics
27. Mendel's Laws
28. - Variations of Mendelism
29. Genetic diseases
30. Sex-linked inheritance
31. Non-sex-linked inheritance
33. TEACHING UNIT 4. GENETIC DIAGNOSTIC TECHNIQUES.
34. Genetic diagnosis
35. Preimplantation genetic diagnosis
36. - Performing PGD
37. - Benefits and disadvantages of performing PGD
38. - Genetic diseases
39. Genetic diagnostic techniques
40. - Cytogenetic tests
41. - Biochemical tests
42. - Molecular tests
43. Genetic screening
44. Regulatory status of preimplantational genetic diagnosis in Spain and other countries
46. UNIT DIDACTIC 5. BIOMARKERS
47. Definition and characteristics of biomarkers
48. Biomarker analysis techniques
49. - Technologies for the identification and validation of new biomarkers
51. UNIT 6. GENETIC COUNSELING IN REPRODUCTION
52. Genetic counseling in reproduction
53. Genetic counseling in Assisted Reproduction
54. Phases involved

MODULE 4. NURSING INTERVENTION IN ASSISTED REPRODUCTION

1. UNIT 1. CONCEPT OF NURSING
2. Definition of Nursing
3. - Chronological tour on the different nursing theories
4. - Florence Nightingale
5. Nursing as a profession
6. - Nursing Code of Ethics
8. UNIT 2. THEORIES AND MODELS IN NURSING
9. Theories and models in nursing
10. - Classification of nursing models and theories
11. Theoretical models
12. - Dorothy Johnson. Behavioral systems model
13. - Dorothea E. Orem. General nursing theory and Self-care theory
14. - Imogene King. Goal attainment theory
15. - Betty Neuman. Systems model
16. - Callista Roy. Adaptation model
18. TEACHING UNIT 3. NURSING CARE PROCESS
19. What is EAP?
20. - Definition of nursing process WHO (1977)
21. - Definition of nursing process by Rosalinda Alfaro (2002)
22. Characteristics of the nursing process
23. Skills needed to apply the EAP
24. Phases of the nursing process
25. - Assessment
26. - Nursing diagnosis
27. - Planning and implementation
28. - Interventions. NIC taxonomy
29. - Assessment
31. UNIT DIDACTIC 4. CARE PLANNING AND EVALUATION.
32. Introduction to the nursing care process
33. Prioritization
34. - Steps to follow in prioritization
35. Developing objectives or expected outcomes or goals with care
36. - Principles of patient-based goals
37. Nursing interventions
38. Care plans
39. Definition of assessment
41. UNIT DIDACTIC 5. CONFIDENTIALITY, RIGHTS AND DUTIES OF THE USER
42. Professional confidentiality
43. - Dimensions of professional confidentiality
44. Informed consent
45. - Elements of informed consent
46. - The written manifestation
47. - Refusal of treatment
48. Rights and duties of the patient
49. - Patient Autonomy Act
50. - General Health Act
51. - Charter of the rights and duties of patients
53. UNIT DIDACTIC 6. STATUTTO MARCO DEL PERSONAL ESTATUTO ESTATUTARIO DE LOS SERVICIOS DE SALUD
54. Introducción al estatuto marco del personal estatutario de los servicios de salud
55. Clasificación del personal estatutario
56. Derechos y deberes del personal estatutario
57. - Adquisición y pérdida de la condición de personal estatutario fijo
58. - Selección de personal temporal y de promoción interna
59. Tiempo de trabajo y régimen de descansos

MODULE 5. INTRODUCTION TO CHRYOBIOLOGY IN ASSISTED REPRODUCTION

1. UNIT 2. CRYOBIOLOGICAL INSTRUMENTATION
2. Good practices with instrumentation.
3. - Cleaning.
4. - Disinfection.
5. - Sterilization.
6. Laboratories.
7. - Accreditations.
8. - Instrument calibration.
9. Rules of order and maintenance in the laboratory.
10. Keys to cryobiology.
11. Cryobiology facilities and rooms.
13. UNIT DIDACTIC 3. FREEZING TECHNIQUES
14. Biosafety.
15. Safe clinical techniques.
16. Types of freezing.
17. - Sperm freezing.
18. - Egg freezing.
19. - Embryo freezing.
21. UNIT DIDACTIC 4. THAWING AND FEASIBILITY STUDY OF FROZEN SAMPLES.
22. Considerations in storage and thawing of samples.
23. Protocol for sample thawing.
24. Factors causing damage during freeze-thaw cycles.
25. - How to reduce damage caused by cycling?
26. Control of sample quality.
27. - Internal and external quality control in the analytical phase.
28. - Reference values.
29. - Laboratory statistics.
31. UNIT 5. SEMEN BANK MANAGEMENT
32. What is a sperm bank?
33. - Human and material resources.
34. Steps to become a donor.
35. Treatment of samples.
36. - Legal framework and current legislation.
37. - Choice of the donor for assisted reproduction treatment.
38. Profile of the patient who resorts to the sperm bank.
40. UNIT 6. CRYOPRESERVATION IN ASSISTED REPRODUCTION
41. Cryopreservation: definition, background and key concepts.
42. - Background.
43. - Key concepts.
44. Positions on cryopreservation.
45. - Ethical-moral.
46. - Bioethics.
47. - Religious.
48. - Pro-conservation.
49. - Restrictive.
50. - Physicochemical principles of cryopreservation.
51. - Osmosis principle.
52. - Cryoscopic descent.
53. - Cryoprotectants.
54. - Classification.
55. The cryogenic agent.
57. UNIT DIDACTIC 7. VITRIFICATION THROUGH CRYOTOP SYSTEM
58. Introduction to vitrification.
59. - Biological parameters.
60. - Damage associated with vitrification.
61. - Types of containers for immersion in liquid nitrogen.
62. What is the Cryotop system?
63. - Material and use.
64. - Types of Cryotop.
65. Experiments performed with the Cryotop vitrification system.
66. - Feasibility of the semi-closed vitrification system with Cryotop.
67. - Validation of the closed Cryotop vitrification system.

MODULE 6. LEGISLATION, RESEARCH AND INNOVATION IN ASSISTED REPRODUCTION

1. UNIT 1. LEGISLATION ON ASSISTED HUMAN REPRODUCTION TECHNIQUES
2. Legislation on assisted human reproduction techniques
3. - Explanatory Memorandum
4. - Chapter I. General provisions
5. - Chapter II. Participants in assisted reproductive techniques
6. - Chapter III. Cryopreservation (sic) and other adjuvant assisted reproductive techniques
7. - Chapter IV. Research with human gametes and pre-embryos
8. - Chapter V. Health centers and biomedical equipment
9. - Chapter VI. National Commission on Assisted Human Reproduction
10. - Chapter VII. National assisted reproduction registries
11. - Chapter VIII. Infringements and penalties
13. UNIT 2. OTHER LAWS REGULATING ASSISTED REPRODUCTION
14. Assisted human reproduction
15. National regulations regulating assisted human reproduction
16. European regulations regulating assisted human reproduction
18. UNIT 3. QUALITY CONTROL AND MANAGEMENT OF AN ASSISTED REPRODUCTION CENTER
19. The ISO 9000 and 9001 standards
20. - ISO 9000
21. - ISO 9001
22. Introduction to the content of UNE-EN ISO 9001:2015
23. The ISO 9001 standard
24. Requirements
26. UNIT DIDACTIC 4. ETHICAL PRINCIPLES IN ASSISTED HUMAN REPRODUCTION
27. What is meant by ethics?
28. - Ethics and values
29. Medical ethics
30. - Ethical, who decides?
31. - Changes in medical ethics
32. Infertility and assisted reproduction
33. - Basic ethical principles
35. UNIT DIDACTIC 5. RESEARCH LINES
36. Research
37. Lines of research in reproductive medicine
38. Endometriosis
39. Fertility preservation
40. - Oocyte vitrification
41. - Sperm cryopreservation
43. UNIT 6. ANESTHESIA IN ASSISTED REPRODUCTION
44. Anesthesia
45. - General anesthesia
46. - Local anesthesia
47. Introductory aspects of anesthetic management in assisted reproduction
48. Anesthetic agents in assisted reproduction
50. UNIT 7. CELL THERAPY AND REGENERATIVE MEDICINE.
51. Introduction to regenerative medicine and cell therapy
52. The cell therapy clinical trial
53. - Coordinating scientific and ethical review
54. - Verification of the understanding of the key aspects of the study by the participating subjects
55. - Publication of the research results

MODULE 7. FINAL MASTER'S PROJECT